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A photoelectrochemical biosensor based on methylene blue sensitized Bi5O7I for sensitive detection of PSA
Xuelian Xiang1, Yanlin Wang1, Yanhui Zhang1
1Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. yuanruo@swu.edu.cn.
Abstract:
Herein, bismuth oxyiodide (Bi5O7I) was used as a signal probe to construct an effective sensitization structure with methylene blue (MB), combined with protein conversion strategy, and a photoelectrochemical (PEC) biosensor was constructed for sensitive detection of prostate-specific antigen (PSA). The designed biosensor had a high sensitivity and a low detection limit (LOD) of 0.047 fg mL-1, which opened up a simple way for the detection of PSA and showed a good application prospect in clinical and medical fields.
