Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Propagation of Uncertainty from Systematic Error01:10

Propagation of Uncertainty from Systematic Error

1.0K
The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.0K
Propagation of Uncertainty from Random Error00:59

Propagation of Uncertainty from Random Error

1.3K
An experiment often consists of more than a single step. In this case, measurements at each step give rise to uncertainty. Because the measurements occur in successive steps, the uncertainty in one step necessarily contributes to that in the subsequent step. As we perform statistical analysis on these types of experiments, we must learn to account for the propagation of uncertainty from one step to the next. The propagation of uncertainty depends on the type of arithmetic operation performed on...
1.3K
Uncertainty: Confidence Intervals00:54

Uncertainty: Confidence Intervals

6.8K
The confidence interval is the range of values around the mean that contains the true mean. It is expressed as a probability percentage. The interpretation of a 95% confidence interval, for instance, is that the statistician is 95% confident that the true mean falls within the interval. The upper and lower limits of this range are known as confidence limits. The confidence limits for the true mean are estimated from the sample's mean, the standard deviation, and the statistical factor...
6.8K
Uncertainty: Overview00:59

Uncertainty: Overview

1.2K
In analytical chemistry, we often perform repetitive measurements to detect and minimize inaccuracies caused by both determinate and indeterminate errors. Despite the cares we take, the presence of random errors means that repeated measurements almost never have exactly the same magnitude. The collective difference between these measurements - observed values - and the estimated or expected value is called uncertainty. Uncertainty is conventionally written after the estimated or expected value.
1.2K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

96.6K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
96.6K
The Uncertainty Principle04:08

The Uncertainty Principle

28.6K
Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
28.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures.

PLoS computational biology·2024
Same author

Geographical distribution of close kin in southern right whales on feeding grounds.

PloS one·2024
Same author

Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod.

Frontiers in physiology·2023
Same author

Evaluating the suitability of close-kin mark-recapture as a demographic modelling tool for a critically endangered elasmobranch population.

Evolutionary applications·2023
Same author

GUBS: Graph-Based Unsupervised Brain Segmentation in MRI Images.

Journal of imaging·2022
Same author

The heritability of BMI varies across the range of BMI-a heritability curve analysis in a twin cohort.

International journal of obesity (2005)·2022

Related Experiment Video

Updated: Oct 14, 2025

Deep Neural Networks for Image-Based Dietary Assessment
13:19

Deep Neural Networks for Image-Based Dietary Assessment

Published on: March 13, 2021

9.4K

Epistemic uncertainty quantification in deep learning classification by the Delta method.

Geir K Nilsen1, Antonella Z Munthe-Kaas1, Hans J Skaug1

  • 1Department of Mathematics, University of Bergen, Norway.

Neural Networks : the Official Journal of the International Neural Network Society
|November 8, 2021
PubMed
Summary
This summary is machine-generated.

We developed an efficient approximation of the Delta method for deep neural networks to quantify epistemic uncertainty. This method accurately estimates uncertainty even with fewer parameters, outperforming traditional approaches.

Keywords:
Deep learningFisher informationHessianNeural networksPredictive epistemic uncertaintyUncertainty quantification

Related Experiment Videos

Last Updated: Oct 14, 2025

Deep Neural Networks for Image-Based Dietary Assessment
13:19

Deep Neural Networks for Image-Based Dietary Assessment

Published on: March 13, 2021

9.4K

Area of Science:

  • Machine Learning
  • Deep Learning
  • Statistical Modeling

Background:

  • The Delta method is a standard technique for quantifying epistemic uncertainty in statistical models.
  • Direct application of the Delta method to deep neural networks is computationally infeasible due to the large number of parameters (P).
  • L2-regularized deep neural networks are widely used but quantifying their uncertainty remains challenging.

Purpose of the Study:

  • To propose a computationally efficient approximation of the Delta method for L2-regularized deep neural networks.
  • To provide theoretical bounds on the approximation error for predictive class probability uncertainty.
  • To demonstrate the practical utility of the proposed method for uncertainty quantification in image classification tasks.

Main Methods:

  • An approximation of the Delta method using the top K eigenpairs of the Fisher information matrix.
  • Efficient computation of approximate eigendecompositions using inverse Hessian, inverse outer-products of gradients, and Sandwich estimators.
  • Analysis of approximation error bounds for predictive uncertainty.

Main Results:

  • The approximation error is minimal when the smallest eigenvalue of the Fisher information matrix approaches the L2-regularization rate, even for K << P.
  • Demonstrated effective uncertainty ranking of images using LeNet and ResNet models on MNIST and CIFAR-10 datasets.
  • False positives exhibited higher predictive epistemic uncertainty than true positives, indicating supplementary information beyond classification.

Conclusions:

  • The proposed low-cost Delta method approximation is effective for uncertainty quantification in deep neural networks.
  • The method provides reliable uncertainty estimates and enables meaningful uncertainty-based image ranking.
  • Predictive epistemic uncertainty offers valuable insights that complement classification results, particularly for identifying challenging or misclassified samples.