Related Experiment Video

Updated: Oct 14, 2025

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

801

Pediatric Medication-overuse Headache and Global Headache Research. A Systematic Review

Manuel Vides-Rosales1

  • 1Pediatric Neurology, Clínica Cefaleas - Centro Médico Escalón, San Salvador, El Salvador; Department of Neurosciences, Medical School, Universidad Dr. Jose Matias Delgado, El Salvador.

Seminars in Pediatric Neurology
|November 9, 2021
PubMed

Insights

Research on pediatric medication-overuse headache (MOH) shows similar publication focus in North America and Europe. Pediatric MOH prevalence ranges from 4-11% in general headache patients, rising significantly in chronic headache cases.

Area of Science:

  • Neurology
  • Pediatric Headache Disorders
  • Epidemiology

Background:

  • Medication-overuse headache (MOH) is a significant clinical concern, yet pediatric research remains limited.
  • Existing literature suggests potential geographical disparities in the perceived importance of adult MOH research between Europe and North America.

Purpose of the Study:

  • To investigate geographical differences in research output concerning pediatric medication-overuse headache (MOH).
  • To analyze the prevalence of pediatric MOH based on published studies.

Main Methods:

  • A correlation analysis was performed between Global Burden of Disease data on headache prevalence and PubMed-searched publications on pediatric MOH (2006-2021).
  • Databases including PubMed, HINARI, and ScienceDirect were searched, yielding 13 studies for pediatric MOH prevalence evaluation across six global regions.
  • Prevalence data were analyzed for pediatric headache patients, chronic headache patients, and those with post-traumatic headaches.

Main Results:

  • North America (28.45%) and Europe (28.54%) exhibit the highest prevalence of headache disorders.
  • The majority of pediatric MOH publications originated from North America (44.2%) and Europe (37.2%).
  • Pediatric MOH prevalence was found to be 4-11% among general pediatric headache patients, increasing to 20-70% in those with chronic headache diagnoses. Higher prevalence was noted in post-traumatic headache cases.

Conclusions:

  • Research efforts on pediatric MOH appear comparably significant in North America and Europe.
  • The prevalence of pediatric MOH varies considerably across studies, with notably higher rates in chronic and post-traumatic headache populations.
  • Further research is warranted to explore the relationship between post-traumatic headache and pediatric MOH prevalence.

Keywords:
Chronic HeadacheGlobal headache disorders prevalenceMOH PrevalencePediatric Medication-overuse headache

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.4K
Investigating Migraine-Like Behavior Using Light Aversion in Mice05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.0K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
31
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
22
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
900
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
21
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.5K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
35