Related Experiment Video
Updated: Oct 14, 2025
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
One-Year Outcome After Endovascular Treatment for Acute Basilar Artery Occlusion
Fengli Li1, Hongfei Sang2, Jiaxing Song1
1Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China (F.L., J. Song, S.L., W.L., J.Y., Z.Q., J.H., L.C., L.L., D.W., W.Z., J. Shuai, Q.Y.).
Insights
Endovascular treatment significantly improves one-year functional outcomes and reduces mortality in acute basilar artery occlusion patients compared to conventional therapy. This study confirms earlier findings at 90 days.
Area of Science:
- Neurology
- Interventional Cardiology
- Clinical Trials
Background:
- Acute basilar artery occlusion is a critical condition with high mortality and disability rates.
- The BASILAR registry is a nationwide prospective study in China evaluating treatments for this condition.
Purpose of the Study:
- To report one-year clinical follow-up results for patients with acute basilar artery occlusion.
- To compare the effectiveness of endovascular treatment versus conventional treatment.
Main Methods:
- Prospective, nonrandomized enrollment of patients from January 2014 to May 2019.
- Primary outcome: modified Rankin Scale at one year, analyzed using ordinal logistic regression.
- Secondary outcomes: functional outcome groups and all-cause mortality at one year.
Main Results:
- One-year data were available for 785 of 829 patients (94.7%).
- Endovascular treatment showed a significant benefit in modified Rankin Scale outcomes (aOR, 4.50; P<0.001).
- One-year mortality was lower with endovascular treatment (54.6%) versus conventional treatment (83.5%) (aOR, 4.36; P<0.001).
Conclusions:
- Endovascular treatment provides a significant beneficial effect on one-year functional outcomes in acute basilar artery occlusion.
- These findings are consistent with the 90-day results from the original study, reinforcing treatment efficacy.
Background And Purpose:
The BASILAR registry, a nationwide prospective nonrandomized study conducted in China, enrolled consecutive patients with acute basilar artery occlusion receiving endovascular treatment or conventional-treatment from January 2014 to May 2019. This article aimed to report the results of clinical follow-up at one year among these patients.
Methods:
The primary outcome was the modified Rankin Scale at one year, assessed as a common odds ratio using ordinal logistic regression analysis adjusted for prespecified prognostic factors. Secondary outcomes included the modified Rankin Scale-based outcome group at one year (0-1, 0-2, or 0-3) and all-cause death.
Results:
Of the 829 patients enrolled in the original BASILAR registry, one-year data were available for 785 patients (94.7%). The distribution of outcomes on the modified Rankin Scale favored endovascular treatment over conventional-treatment (adjusted common odds ratio, 4.50 [95% CI, 2.81-7.29]; P<0.001). The cumulative one-year mortality rate was 54.6% in the endovascular treatment group versus 83.5% in the conventional-treatment group (adjusted odds ratio, 4.36 [95% CI, 2.69-7.29]; P<0.001).
Conclusions:
The beneficial effect of endovascular treatment on functional outcome at one year in patients with acute basilar artery occlusion is similar to that reported at 90 days in the original study.
Registration:
URL: http://www.chictr.org.cn; Unique identifier: ChiCTR1800014759.
