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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Treatment landscape of triple-negative breast cancer - expanded options, evolving needs

Giampaolo Bianchini1,2, Carmine De Angelis3,4, Luca Licata5

  • 1Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy. bianchini.giampaolo@hsr.it.

Nature Reviews. Clinical Oncology
|November 10, 2021
PubMed

Insights

Triple-negative breast cancer (TNBC) has poor outcomes due to heterogeneity. Advances reveal TNBC as an ecosystem, leading to novel targeted therapies like PARP inhibitors and immune-checkpoint inhibitors.

Area of Science:

  • Oncology
  • Cancer Biology
  • Immunology

Background:

  • Triple-negative breast cancer (TNBC) presents significant therapeutic challenges due to tumor heterogeneity and limited effective treatments beyond chemotherapy.
  • TNBC is associated with the least favorable outcomes among breast cancer subtypes.

Purpose of the Study:

  • To review the current and emerging therapeutic landscape for TNBC.
  • To discuss the significance of TNBC ecosystem, encompassing tumor-immune interactions and cancer cell features, for treatment tailoring.

Main Methods:

  • Review of recent advances in omics technologies and their impact on understanding TNBC biology.
  • Analysis of novel targeted agents and their clinical implications for TNBC treatment.

Main Results:

  • Omics technologies have illuminated the heterogeneity of the TNBC microenvironment and its dynamic relationship with cancer cells.
  • Novel targeted therapies, including PARP inhibitors, antibody-drug conjugates, and immune-checkpoint inhibitors, are transforming TNBC treatment for both early-stage and advanced disease.

Conclusions:

  • A comprehensive view of TNBC as an ecosystem, integrating intrinsic and extrinsic features, is crucial for advancing treatment strategies.
  • Tailoring treatment based on an integrated understanding of the TNBC ecosystem offers improved opportunities for patient benefit.
  • Numerous new compounds and combinations are under development, presenting ongoing challenges and opportunities for clinical translation.

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