Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
Ying Chen1,2,3, Ruya You1,2,3, Ke Wang1,2,3
1Beijing Advanced Innovation Centre for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, China.
Evidence-Based Complementary and Alternative Medicine : Ecam
|November 10, 2021
Summary
Discovering new inhibitors for human urate anion transporter 1 (hURAT1) is key to treating hyperuricemia. This review covers methods to assay hURAT1 inhibition and recent progress in finding novel inhibitors.
Area of Science:
- Nephrology
- Pharmacology
- Biochemistry
Background:
- Human urate anion transporter 1 (hURAT1) facilitates uric acid reabsorption in renal tubules.
- Hyperuricemia treatment is a focus, with hURAT1 as a therapeutic target.
- Existing hURAT1 inhibitors like benzbromarone have side effects, driving the need for alternatives.
Purpose of the Study:
- To review methods for evaluating hURAT1 inhibition.
- To summarize recent advancements in identifying new hURAT1 inhibitors.
- To provide an overview of natural and synthetic compounds targeting hURAT1.
Main Methods:
- Literature review of scientific databases.
- Analysis of published assays for hURAT1 inhibition.
- Compilation of data on natural and synthetic hURAT1 inhibitors discovered in the last five years.
Main Results:
- Various methods exist for assaying hURAT1 inhibition.
- Progress has been made in discovering novel natural and synthetic hURAT1 inhibitors.
- The review consolidates findings from the past five years.
Conclusions:
- Developing effective hURAT1 inhibitors is crucial for managing hyperuricemia.
- Continued research into novel inhibitors and assay technologies is warranted.
- This review serves as a resource for understanding current progress in hURAT1 inhibition.
