Intestinal Multi-Target Mechanisms of Natural Active Substances in Hyperuricemia Alleviation: Recent Progress.
Ying Chen1, Ziling Pan1, Hongyan Li1
1Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Beijing 100080, China.
Nutrients
|March 28, 2026
Summary
Natural compounds target the intestine to regulate uric acid (UA) levels, offering a safer approach to managing hyperuricemia. This review explores gut mechanisms and natural substances for potential new treatments.
Area of Science:
- Metabolic disorders
- Gastroenterology
- Pharmacology
Background:
- Hyperuricemia, characterized by high serum uric acid (UA), leads to gout and kidney issues.
- Current treatments for hyperuricemia often cause adverse effects.
- The intestine is recognized as a key regulator of UA homeostasis, presenting a new therapeutic target.
Purpose of the Study:
- To review intestinal mechanisms controlling UA regulation.
- To evaluate natural active substances targeting these gut-mediated pathways for hyperuricemia treatment.
Main Methods:
- Systematic review of preclinical studies on intestinal UA metabolism.
- Analysis of gut microbiota, urate transporters, barrier function, and inflammation.
- Evaluation of natural substances like polyphenols, polysaccharides, and peptides.
Main Results:
- Natural substances modulate gut microbiota composition.
- These substances enhance UA intestinal excretion and intestinal barrier function.
- Natural compounds effectively suppress inflammatory pathways linked to hyperuricemia.
Conclusions:
- Natural active substances demonstrate multi-target efficacy in the intestine for hyperuricemia.
- Intestinal interventions using natural compounds offer a promising therapeutic strategy.
- Further research into nutrition-based and pharmacological treatments targeting the gut is warranted.
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