Related Experiment Video

Updated: Oct 14, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.5K

Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial

Min Gyu Kang1, Bon-Kwon Koo2, Udaya S Tantry3

  • 1Department of Internal Medicine, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea.

JACC. Basic to Translational Science
|November 10, 2021
PubMed

Insights

Heightened thrombogenicity, measured by high platelet-fibrin clot strength, is linked to coronary microvascular dysfunction (CMD) in acute myocardial infarction (AMI) patients. This association impacts the risk of ischemic events post-reperfusion.

Area of Science:

  • Cardiology
  • Hematology
  • Vascular Biology

Background:

  • The relationship between thrombogenicity and coronary microvascular dysfunction (CMD) in acute myocardial infarction (AMI) patients remains under-investigated.
  • Understanding this link is crucial for improving post-reperfusion outcomes in AMI.

Purpose of the Study:

  • To investigate the association between thrombogenicity and CMD in patients with AMI.
  • To explore the prognostic implications of heightened thrombogenicity and CMD on ischemic events.

Main Methods:

  • Real-world clinical data from 116 AMI patients.
  • Thrombogenicity assessed using thromboelastography and conventional hemostatic measures.
  • Coronary microvascular dysfunction (CMD) defined by index of microcirculatory resistance >40 U via invasive physiologic testing.

Main Results:

  • High platelet-fibrin clot strength (P-FCS) (≥68 mm) significantly increased the risk of postprocedural CMD (OR: 4.35; 95% CI: 1.74-10.89).
  • Patients with both CMD and high P-FCS exhibited a higher rate of ischemic events (OR: 5.58; 95% CI: 1.31-23.68) compared to those without CMD and low P-FCS.

Conclusions:

  • A significant association exists between heightened thrombogenicity and CMD in AMI patients.
  • This combination has important prognostic implications for ischemic events following reperfusion therapy.

Keywords:
AMI, acute myocardial infarctionCFR, coronary flow reserveCMD, coronary microvascular dysfunctionIMR, index of microcirculatory resistanceLASSO, least absolute shrinkage and selection operatorMA, maximum amplitudeMACE, major adverse cardiovascular eventsOR, odds ratioP-FCS, platelet-fibrin clot strengthPCI, percutaneous coronary interventionPRU, P2Y12 reaction unitsR, reaction timeTEG, thromboelastographyTIMI, Thrombolysis in Myocardial InfarctionTmn, mean transit timeacute myocardial infarctioncardiovascular eventclot strengthcoronary microvascular dysfunctionthrombogenicity

More Related Videos

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.6K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
43
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
79
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
397
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
115
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
81
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
63