The effect of aspirin on serum immunoglobulins

After discontinuing aspirin products for seven days, 21 aspirin tolerant adults were given 650 mg of aspirin daily for one week. Serum immunoglobulins (IgG, IgA, IgM, and IgE), complete blood count (CBC), and total eosinophil counts (TEC) were determined before aspirin challenge, four hours after initial challenge, on day seven of aspirin ingestion, 24 hours after discontinuing aspirin, and three weeks after discontinuing aspirin. No significant changes were noted in any of these categories. Although aspirin is an anti-inflammatory drug similar to corticosteroids, it does not produce immunological changes that corticosteroids produce as determined by these parameters.