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Food hypersensitivity as a pathogenic factor in atopic dermatitis.
New England and Regional Allergy Proceedings
|November 1, 1986
Summary
Food hypersensitivity significantly impacts severe atopic dermatitis in children. Oral food challenges confirmed allergies in 59%, with elimination diets improving symptoms for most patients.
Area of Science:
- Immunology
- Dermatology
- Allergy
Background:
- Atopic dermatitis pathogenesis is complex, with the role of food hypersensitivity long debated.
- Understanding food allergy's contribution is crucial for managing severe pediatric atopic dermatitis.
Purpose of the Study:
- To investigate the prevalence and impact of food hypersensitivity in children with severe atopic dermatitis.
- To assess the efficacy of diagnosis and dietary intervention for food allergy in this patient group.
Main Methods:
- A cohort of 132 children with severe atopic dermatitis underwent double-blind, placebo-controlled oral food challenges.
- Food hypersensitivity was identified through immediate hypersensitivity responses during challenges.
Main Results:
- 59% of children with severe atopic dermatitis exhibited immediate hypersensitivity to at least one food.
- Accurate diagnosis of food allergy and subsequent elimination diets led to significant clinical improvement in most affected children.
Conclusions:
- Food hypersensitivity is a significant factor in a majority of children with severe atopic dermatitis.
- Diagnosis and management of food allergy through elimination diets offer a viable therapeutic strategy for improving atopic dermatitis outcomes.