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Corticosteroids and theophylline clearance.

E N Squire, H S Nelson

New England and Regional Allergy Proceedings

|March 1, 1987

Summary

This summary is machine-generated.

Corticosteroids may alter theophylline clearance in some patients. Further research is needed to confirm if short-term oral corticosteroid use impacts theophylline drug disposition.

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Area of Science:

Pharmacology
Clinical Pharmacy

Background:

The impact of corticosteroids on theophylline disposition is not well-established.
Conflicting reports exist regarding changes in theophylline clearance with steroid use in asthma treatment.

Purpose of the Study:

To investigate the effect of corticosteroid administration on theophylline pharmacokinetics.
To determine if corticosteroid therapy alters theophylline clearance in healthy adults.

Main Methods:

The study involved administering corticosteroids to normal adult subjects.
Theophylline kinetics were assessed before and after corticosteroid treatment.

Main Results:

Theophylline clearance remained unchanged in two subjects after corticosteroid administration.

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One subject exhibited significantly increased theophylline clearance following corticosteroid treatment.

Conclusions:

Short-term oral corticosteroid use may affect theophylline disposition in certain individuals.
Additional studies are required to fully elucidate the relationship between corticosteroids and theophylline pharmacokinetics.