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Updated: Oct 14, 2025

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Mucoadhesion: mucin-polymer molecular interactions.

Quoc Dat Pham1, Sofi Nöjd2, Martin Edman2

  • 1Department of Food Technology, Lund University, P.O. Box 124, 22100 Lund, Sweden; R&D Product Design, McNeil AB, Box 941, 25109 Helsingborg, Sweden; Division of Physical Chemistry, Chemistry Department, Lund University, P.O. Box 124, 22100 Lund, Sweden.

International Journal of Pharmaceutics
|November 10, 2021
PubMed
Summary
This summary is machine-generated.

Mucoadhesion mechanisms were clarified using Nuclear Magnetic Resonance (NMR) to understand polymer interactions with mucin. Findings reveal specific interaction sites and factors influencing mucoadhesion, aiding drug delivery and food applications.

Keywords:
DynamicsHydrationMobilityNMRRheology

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Mucoadhesion enhances drug absorption and influences sensory perception in oral applications.
  • Understanding mucoadhesion mechanisms is crucial for optimizing mucoadhesive product development.
  • Existing in-vitro methods yield contradictory results on polymer mucoadhesive properties.

Purpose of the Study:

  • To investigate molecular interactions between various polymers and bovine submaxillary mucin.
  • To elucidate the role of polymer properties (charge, degree of polymerization) in mucoadhesion.
  • To provide atomically resolved insights into mucin conformational mobility upon polymer interaction.

Main Methods:

  • Utilized 1H Nuclear Magnetic Resonance (NMR) spectroscopy to analyze polymer-mucin interactions at pH 6.6.
  • Examined polymers with diverse chemical structures and degrees of polymerization (DP).
  • Interpreted NMR linewidths and signal intensities to differentiate interaction types and effects on mucin mobility.

Main Results:

  • Identified distinct mucin interaction sites for positively charged poly(ethyleneimine) compared to other charged polymers.
  • Demonstrated that polymer DP, concentration, and dehydration significantly influence mucoadhesion.
  • Distinguished between specific segmental interactions and universal mobility effects of polymers on mucin.

Conclusions:

  • Molecular insights into polymer-mucin interactions are critical for developing advanced mucoadhesive formulations.
  • NMR provides a powerful tool for characterizing mucoadhesion at a molecular level.
  • Findings impact the design of pharmaceutical and food products leveraging mucoadhesion for enhanced performance.