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Related Concept Videos

Papillary Dermis01:11

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The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The Retinoblastoma Gene01:20

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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Classification of Epithelial Tissues: Overview01:22

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Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
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Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Adenodermatofibroma: a rare variant.

Kristen Russomanno1, Min Deng, Michael Cardis

  • 1Department of Dermatology, Medstar Washington Hospital Center, Georgetown University Hospital, Washington, DC Department of Internal Medicine, Medstar Washington Hospital Center, Washington, DC. kristen.l.russomanno@medstar.net.

Dermatology Online Journal
|November 10, 2021
PubMed
Summary
This summary is machine-generated.

Adenodermatofibroma, a rare variant of fibrous histiocytoma, presents unique histopathologic findings. This case report details its presentation and discusses the origin of apocrine glands within these benign skin lesions.

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Fibrous histiocytoma, also known as dermatofibroma, is a common benign skin neoplasm.
  • Adenodermatofibroma is a recently identified variant with limited reported cases.

Observation:

  • A case of adenodermatofibroma presented as a large, firm, atrophic plaque on the thigh.
  • Histopathology revealed dilated glandular structures with apocrine features within a fibrohistiocytic infiltrate.

Findings:

  • The histopathologic features confirmed the diagnosis of adenodermatofibroma.
  • Dilated glandular structures with apocrine differentiation are characteristic of this variant.

Implications:

  • Understanding adenodermatofibroma's distinct features aids in accurate diagnosis and differential diagnosis.
  • Further research into the origin of apocrine glands in these lesions is warranted.