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Immunomodulators for Non-Melanoma Skin Cancers: Updated Perspectives
Kristen Russomanno1, Sara Abdel Azim2, Vishal A Patel3
1Department of Dermatology, Medstar Georgetown University Hospital/Medstar Medical Group, Washington, DC, USA.
Clinical, Cosmetic and Investigational Dermatology
|April 25, 2023
Summary
Non-melanoma skin cancers (NMSCs) are common globally. This review details immunomodulatory drugs for preventing and treating NMSCs and precursor lesions, aiding personalized patient care.
Area of Science:
- Dermatology
- Oncology
- Immunology
Background:
- Non-melanoma skin cancers (NMSCs) represent the most prevalent cancers worldwide.
- These cancers pose significant morbidity and mortality risks, particularly in immunosuppressed individuals.
- Effective NMSC management necessitates integrated primary, secondary, and tertiary prevention strategies.
Purpose of the Study:
- To provide an updated overview of topical and systemic immunomodulatory drugs for NMSC prevention and treatment.
- To review the clinical evidence supporting the use of these agents.
- To emphasize the importance of identifying high-risk patients for reduced disease burden.
Main Methods:
- Systematic literature review of immunomodulatory drugs for NMSC.
- Analysis of clinical data on efficacy in preventing and treating NMSC and actinic keratoses (AKs).
- Evaluation of drug use in various risk categories of NMSC.
Main Results:
- Multiple systemic and topical immunomodulatory drugs are available and clinically integrated.
- These drugs demonstrate efficacy in managing precursor lesions (AKs), low-risk NMSC, and advanced disease.
- Patient risk stratification is crucial for optimizing treatment selection.
Conclusions:
- Immunomodulatory drugs offer valuable options for NMSC prevention and treatment.
- Personalized treatment regimens based on patient risk and drug efficacy are essential.
- Continued research and understanding of NMSC pathophysiology inform therapeutic advancements.
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