Related Experiment Video
Updated: Oct 13, 2025
Manipulating the Murine Lacrimal Gland
Published on: November 18, 2014
Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands
Reydson Alcides de Lima-Souza1,2, Natália de Magalhães Rodrigues2, João Figueira Scarini1,2
1Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Purpose:
To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG).
Methods:
Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases.
Results:
Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples.
Conclusions:
In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.
