Related Experiment Video
Updated: Oct 13, 2025

08:18
Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
Published on: October 4, 2024
1.3K
sLRP1'in up retinol keeps the gut SAAfe
Jasmine Labuda1, Oliver J Harrison2
1Center for Fundamental Immunology, Benaroya Research Institute, 1201 9(th) Ave., Seattle, WA 98101, USA.
Immunity
|November 10, 2021
Abstract:
Retinol is shuttled to myeloid cells for conversion to retinoic acid, but the receptor facilitating uptake of SAA:retinol complexes on myeloid cells is unknown. In a recent issue of Science, Bang et al. (2021) use genetic and biochemical approaches to reveal this critical receptor to be LRP1 and show that this axis is essential for intestinal innate and adaptive immune responses.

