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Measuring Material Microstructure Under Flow Using 1-2 Plane Flow-Small Angle Neutron Scattering

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Published on: February 6, 2014

Starch flow behavior alone and under different glidants action using the shear cell method.

Paulo J Salústio¹, Maria F Monteiro², Telmo Nunes³

¹Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.

Drug Development and Industrial Pharmacy

|November 11, 2021

Summary

This summary is machine-generated.

Colloidal silicon dioxide (CSD) significantly improved the flowability of pregelatinised starch, unlike talc, which showed no notable effect. Powder flow testing revealed CSD enhances powder flow, while talc does not improve starch

Keywords:

Powder behavior colloidal silicon dioxide flow index glidants pregelatinised starch shear cell talc

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Area of Science:

Pharmaceutical Sciences
Materials Science
Chemical Engineering

Background:

Powder flowability is critical for pharmaceutical manufacturing processes like tablet compression and capsule filling.
Poor powder flow can lead to production inefficiencies and inconsistent product quality.
Glidants are commonly added to improve powder flow characteristics.

Purpose of the Study:

To evaluate the flow behavior of pregelatinised starch.
To investigate the impact of talc and colloidal silicon dioxide (CSD) as glidants on starch flow.
To compare the efficacy of different powder flow testing methods.

Main Methods:

Conventional methods: Angle of Repose, Bulk and Tapped densities, Compressibility Index.
Shear cell methods: Brookfield Powder Flow Tester, measuring Flow Index (ffc) under varying consolidation stress.
Evaluation of parameters like effective angle of internal friction and wall friction, critical arching, and rathole formation.

Main Results:

Talc did not significantly alter the flow behavior of pregelatinised starch, with Flow Index values indicating cohesive to very cohesive powder.
Colloidal silicon dioxide (CSD) demonstrably improved starch flowability, with Flow Index values ranging from cohesive to easy-flowing as consolidation stress increased.
Powder Flow Tester method provided more comprehensive and consistent results compared to conventional methods.

Conclusions:

Colloidal silicon dioxide is an effective glidant for improving the flow properties of pregelatinised starch under the tested conditions.
Talc is ineffective as a glidant for pregelatinised starch in this study.
The Powder Flow Tester offers a more complete characterization of powder flow behavior relevant to industrial applications.