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Related Experiment Video

Updated: Oct 13, 2025

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
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Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery.

Satoshi Maesawa1,2, Epifanio Bagarinao1,3, Daisuke Nakatsubo2,4

  • 1Brain & Mind Research Center, Nagoya University Graduate School of Medicine.

Neurologia Medico-Chirurgica
|November 11, 2021
PubMed
Summary

Resting-state functional MRI reveals altered brain networks in focal epilepsy patients. Aberrant hubs near the epileptogenic zone correlate with seizure outcomes, suggesting earlier surgery may improve results.

Keywords:
default mode networkepilepsylarge-scale networkpreoperative evaluationresting-state functional MRI

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Epilepsy Research

Background:

  • Resting-state functional MRI (rs-fMRI) is key for mapping brain networks.
  • Focal epilepsy involves complex network disruptions.
  • Understanding these disruptions is crucial for treatment.

Purpose of the Study:

  • To assess multitier network analysis using rs-fMRI in focal epilepsy.
  • To investigate structural and functional network changes.
  • To explore the relationship between cortical hubs, the epileptogenic zone, and cognitive networks.

Main Methods:

  • Retrospective analysis of 20 epilepsy patients using rs-fMRI and structural MRI.
  • Voxel-based morphometry for structural analysis.
  • Dual-regression and spectral dynamic causal modeling (spDCM) for network and hub analysis.

Main Results:

  • No significant structural differences were found between groups.
  • Decreased functional connectivity observed in multiple networks, including the default mode network (DMN).
  • Aberrant hubs near the epileptogenic zone (EZ hubs) found in 85% of patients, correlating with positive surgical outcomes.

Conclusions:

  • Epilepsy is associated with pathological alterations in large-scale brain networks.
  • EZ hubs may facilitate secondary seizure foci and impair cognitive networks like the DMN.
  • Earlier surgical intervention in focal epilepsy may lead to better outcomes.