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Related Experiment Videos

Long-term mandibular adaptations to protrusive function: an experimental study in Macaca mulatta.

J A McNamara, F A Bryan

    American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
    |August 1, 1987
    PubMed
    Summary
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    Induced protrusive function significantly increased mandibular length in juvenile rhesus monkeys. This study indicates mandibular length is adaptable, not genetically predetermined.

    Area of Science:

    • Primate craniofacial development
    • Skeletal adaptation research
    • Mandibular growth studies

    Background:

    • Understanding mandibular growth is crucial for orthodontics and maxillofacial surgery.
    • Previous research has explored genetic and functional influences on jaw development.
    • The role of functional stimuli in long-term skeletal adaptation remains an area of investigation.

    Purpose of the Study:

    • To investigate long-term mandibular adaptations in response to experimentally induced protrusive function.
    • To determine if induced functional changes can alter mandibular growth patterns.
    • To challenge the concept of a genetically predetermined mandibular length.

    Main Methods:

    • Experimental study involving 23 male juvenile rhesus monkeys (Macaca mulatta).

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  • 11 animals received serial protrusive appliances to induce forward jaw positioning.
  • Cephalometric analysis was used to monitor mandibular adaptations over 144 weeks; 12 animals served as controls.

    • Main Results:

    • Significant increases in condylar growth and overall mandibular length were observed in the experimental group after 48 weeks.
    • At 144 weeks, the mandibles of treated animals were 5-6 mm longer than those of control animals.
    • These findings demonstrate a substantial adaptive response of the mandible to functional changes.

    Conclusions:

    • The mandible exhibits significant adaptability to functional stimuli, demonstrating plasticity in growth.
    • The results do not support the hypothesis that mandibular length is solely genetically predetermined.
    • Functional appliance therapy may influence long-term craniofacial skeletal development.