Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.4K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.5K
The Thyroid Gland01:23

The Thyroid Gland

4.7K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.7K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

31
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
31
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

2.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.2K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

941
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
941

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity Interpreter: A Digital Tool for Assessment of Childhood Obesity.

Indian pediatrics·2026
Same author

ICMJE Recommendations (2026) on the Use of Artificial Intelligence in Scientific Writing.

Indian pediatrics·2026
Same author

BRAFV600E and KRAS Mutation in Thyroid Lesions: A Study on Giemsa-Stained Fine-Needle Aspiration Archival Smears.

Acta cytologica·2026
Same author

Apolipoproteins, lipoprotein(a), and conventional markers of dyslipidemia in children with nephrotic syndrome in disease remission.

Journal of clinical lipidology·2026
Same author

Low Dose Versus High Dose Vitamin D for Treatment of Nutritional Rickets: A Systematic Review and Meta-analysis.

Indian pediatrics·2026
Same author

RASP: rapid antibody functional screening by pentavalent phage display.

mAbs·2026
Same journal

Development and Validation of a Comprehensive Obesity Assessment Tool: Integrating Lifestyle, Body Image, and Past Weight Management.

Indian journal of endocrinology and metabolism·2026
Same journal

The Indian Obesity Paradox- Low in Muscle, High in Fat.

Indian journal of endocrinology and metabolism·2026
Same journal

Serial Changes in Thyroid Hormones with Oral or Intravenous Bisphosphonates.

Indian journal of endocrinology and metabolism·2026
Same journal

Role of Serum Triiodothyronine-to-Thyroxine Ratio and Thyroid Colour Flow Doppler in Differentiation of Graves' Disease from Destructive Thyroiditis.

Indian journal of endocrinology and metabolism·2026
Same journal

Efficacy of Fixed Low-Dose Weekly Subcutaneous Testosterone Self-Administration in Transgender Male Patients in India.

Indian journal of endocrinology and metabolism·2026
Same journal

What Works in Type 2 Diabetes: Intermittent Fasting or Calorie Restriction or Both?

Indian journal of endocrinology and metabolism·2026
See all related articles

Related Experiment Video

Updated: Oct 13, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.0K

Thyroid Dysfunction in COVID-19.

Aashima Dabas1, Harpreet Singh2, Binita Goswami3

  • 1Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

Indian Journal of Endocrinology and Metabolism
|November 11, 2021
PubMed
Summary
This summary is machine-generated.

Thyroid dysfunction, particularly low triiodothyronine (fT3), is common in hospitalized COVID-19 patients. Low fT3 levels indicate increased inflammation and a higher risk of death, suggesting a poor prognosis.

Keywords:
HypothyroidismIL-6inflammatory markersick euthyroidthyroiditis

More Related Videos

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.0K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K

Related Experiment Videos

Last Updated: Oct 13, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.0K
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

1.0K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.9K

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 can impact various organ systems, including the endocrine system.
  • Thyroid function abnormalities have been reported in viral infections, but their role in COVID-19 severity is not fully understood.

Purpose of the Study:

  • To investigate the prevalence of thyroid dysfunction in patients hospitalized with COVID-19.
  • To determine the association between thyroid dysfunction and COVID-19 disease severity.

Main Methods:

  • Recruitment of 164 COVID-19 patients without pre-existing thyroid disease over three months.
  • Exclusion of patients with prior thyroid conditions.
  • Assessment of thyroid function tests and correlation with interleukin-6 (IL-6) levels.

Main Results:

  • Thyroid dysfunction was observed in a significant proportion of patients, with no statistically significant difference across disease severity groups (mild, moderate, severe).
  • Sick euthyroid syndrome, characterized by low free triiodothyronine (fT3), was the most common abnormality (53.7%).
  • Declining fT3 levels correlated with increased disease severity (P=0.011), and low fT3 was significantly associated with mortality (OR 2.634, P=0.031) and elevated IL-6 levels (OR 2.575, P=0.021).

Conclusions:

  • Sick euthyroid syndrome is prevalent in hospitalized COVID-19 patients.
  • Low fT3 levels are linked to increased inflammation and predict a poorer prognosis, including a higher risk of death.