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A systematic analysis on the clinical safety and efficacy of onco-virotherapy

Darshak K Bhatt1,2, Lieske Wekema1, Luciana Rodrigues Carvalho Barros2

  • 1Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.

Molecular Therapy Oncolytics
|November 11, 2021
PubMed

Insights

Onco-virotherapy shows promise for cancer treatment, but more controlled clinical trials are needed. Current research often focuses on safety over immune responses, highlighting a gap in understanding its full therapeutic potential.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Onco-virotherapy utilizes viruses to target and destroy cancer cells.
  • Several onco-virotherapy agents are approved or in clinical trials for cancer treatment.

Purpose of the Study:

  • To systematically review the clinical impact of onco-virotherapy compared to other cancer therapies.
  • To analyze trial design, patient characteristics, therapy, delivery, and outcomes in onco-virotherapy studies.

Main Methods:

  • Systematic review of clinical studies from ClinicalTrials.gov, PubMed, and EMBASE.
  • Analysis of trial design, patient demographics, therapeutic strategies, and reported outcomes.

Main Results:

  • Most studies involved advanced/metastatic tumors, using diverse vectors, primarily administered intratumorally.
  • Therapeutic safety was the main outcome assessed; immunological antitumor responses were less frequently studied.
  • Only 59 of 896 studies were randomized controlled trials providing comparative data.

Conclusions:

  • There is a need for more rigorous, controlled clinical studies in onco-virotherapy.
  • Further research should focus on comparative efficacy and immunological responses to optimize treatment strategies.
Keywords:
cancerclinical studyimmune responseoncolytic virotherapyoutcomessystematic reviewtrial

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