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Hypercoagulability of COVID-19 and Neurological Complications: A Review

Patrick Moore1, Fatema Esmail1, Shuai Qin1

  • 1Loyola University Medical Center Department of Internal Medicine Division of Hematology and Oncology, United States.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|November 11, 2021
PubMed

Insights

The SARS-CoV-2 virus, causing COVID-19, can lead to severe neurologic complications. This review examines COVID-19

Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Background:

  • The emergence of SARS-CoV-2 has led to millions of deaths globally.
  • Hospitalized COVID-19 patients frequently exhibit acute changes in mental status, cognition, and encephalopathy.
  • Neurologic complications may arise from systemic infection severity, direct viral invasion of the CNS, or immune-mediated mechanisms.

Purpose of the Study:

  • To review the current understanding of neurologic complications associated with SARS-CoV-2 infection.
  • To explore the relationship between COVID-19 and hemostasis.
  • To discuss current treatment, prevention, and vaccination strategies for COVID-19.

Main Methods:

  • Literature review of existing research on COVID-19 and its neurological effects.
  • Analysis of studies investigating the mechanisms behind COVID-19-related neurological complications.
  • Examination of data on hemostasis, treatment, prevention, and vaccination in the context of COVID-19.

Main Results:

  • Neurologic manifestations are a significant concern in COVID-19 patients.
  • Multiple pathways, including direct viral invasion and immune responses, contribute to neurological damage.
  • Understanding COVID-19's impact on hemostasis is crucial for patient management.

Conclusions:

  • COVID-19 poses a substantial risk for neurological complications.
  • Further research is needed to fully elucidate the mechanisms and optimize management strategies.
  • Comprehensive approaches including vaccination are vital for controlling the pandemic.

Keywords:
AnticoagulationCOVID-19Neurologic outcomesSARS-CoV-2

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