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Serum leukocyte cell-derived chemotaxin 2 level is associated with atopic dermatitis patients
Keyu Zhao1, Feng Xu2, Xinyu Jiang1
1Department of Dermatology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China; Central Laboratory, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China.
Background:
Atopic dermatitis (AD) is a chronic skin inflammation with a heterogeneous immunological profile. Leukocyte cell-derived chemotaxin 2 (LECT2) is a liver-derived multifunctional cytokine that has been studied due to its important role in inflammatory and autoimmune diseases. However, the relationship between AD and LECT2 has not been defined. This study was performed to investigate the levels of LECT2 in patients with AD and to determine whether it was associated with the severity and clinical characteristics of AD.
Methods:
The study included 42 AD patients and 30 healthy controls from the Affiliated Hospital of Medical School of Ningbo University. Participants' serum levels of LECT2 were measured using enzyme-linked immunosorbent assay kits. The values in the patient group and control group were statistically compared. The relationships between the different markers were evaluated by correlation analysis.
Results:
The serum levels of LECT2 were significantly higher in AD patients than those in the controls. In addition, LECT2 was significantly correlated with the Scoring of Atopic Dermatitis (SCORAD) index, the level of immunoglobulin E (IgE), and eosinophils (P<0.01, for all 3).
Conclusions:
Serum LECT2 levels were evaluated in AD patients. The results showed that LECT2 may be a useful biomarker of AD, and may participate in the occurrence and regulation of inflammation in AD progression.
