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Updated: Oct 13, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Systematic review and meta-analysis of the CT imaging characteristics of infectious pneumonia
Yali Liu1, Xiaohuan Zhou2, Xiao Liu1
1Pingdingshan University Medical College, Pingdingshan, China; Philippine Women's University School of Nursing, Manila, Philippines.
Insights
Computed tomography (CT) scans reveal common signs of COVID-19 pneumonia, including ground-glass opacity and pleural thickening. These CT findings are crucial for diagnosing infectious pneumonia caused by SARS-CoV-2.
Area of Science:
- Radiology
- Infectious Diseases
- Pulmonology
Background:
- The emergence of COVID-19 (Coronavirus Disease 2019) in Wuhan, China, in December 2019, led to a global health crisis.
- Early studies on COVID-19 clinical characteristics had limited sample sizes and varied findings.
- Accurate diagnosis and understanding of disease patterns are essential for patient management.
Purpose of the Study:
- To systematically review and synthesize the computed tomography (CT) imaging findings in patients with COVID-19.
- To identify the most common and characteristic CT signs associated with SARS-CoV-2 infection.
- To evaluate the utility of CT in diagnosing infectious pneumonia.
Main Methods:
- A comprehensive literature search was conducted in Chinese and English databases.
- Keywords included "Infectious pneumonia", "COVID-19", "CT", "SARS-CoV-2", and "Diagnose".
- Meta-analysis was performed using Rev Man 5.3 software to assess the quality of included studies and synthesize results.
Main Results:
- Ground-glass opacity was the most frequent CT finding (95% CI: 0.79-0.97).
- Other common signs included vascular thickening (95% CI: 0.63-0.78) and pleural thickening (95% CI: 0.02-0.15).
- Lesions were predominantly subpleural and often distributed within a single lobe, with various morphologies like patchy and nodular patterns.
Conclusions:
- Ground-glass opacity is a typical CT manifestation of COVID-19 pneumonia.
- CT imaging plays a vital role in the diagnosis of SARS-CoV-2 infection.
- Understanding these CT patterns aids in early detection and management of infectious pneumonia.
Background:
Since December 2019, there have been cases of infectious pneumonia of unknown cause in Wuhan, Hubei Province, China. On January 12, 2020, the World Health Organization (WHO) named it COVID-19. There are few studies on the clinical characteristics of patients with COVID-19, and results vary widely in sample sizes.
Methods:
Chinese and English databases were searched with "Infectious pneumonia", "COVID-19", "CT", "SARS-COV-2", and "Diagnose" as keywords. Rev Man 5.3 software provided by the Cochrane system was used to assess the quality of the included literature.
Results:
Of the 18 included studies, ground-glass shadow was the most common computed tomography (CT) sign [95% confidence interval (CI): 0.79-0.97], followed by thickening of the blood vessels (95% CI: 0.63-0.78), and pleural thickening (95% CI: 0.02-0.15). Of the 18 studies, 12 reported that the lesions were externally subpleural (95% CI: 0.132-0.173), and 6 reported that the lesions were distributed in a single lobe (95% CI: 0.598-0.841). The heterogeneity test results showed that the morphology of the lesions was cord-like (95% CI: 0.092-0.172), grid-like (95% CI: 0.152-0.193), patchy (95% CI: 0.192-0.313), and nodular (95% CI: 0.591-0.745).
Discussion:
Ground-glass opacity was a typical CT manifestation for patients with infectious pneumonia, and CT signs were instrumental in diagnosing this disease.
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