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Updated: Oct 13, 2025

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Complex motion series performance differs between previously untreated patients with Parkinson's disease and controls
Thomas Müller1, Wilfried Kuhn2
1Department of Neurology, St. Joseph Hospital Berlin-Weissensee, Gartenstr. 1, 13088, Berlin, Germany. th.mueller@alexianer.de.
Abstract:
Motor behaviour in patients with Parkinson's disease is determined with instrumental tests and rating procedures. Results mirror impairment of an individual patient. Objectives were to determine the associations between two kinds of motion series and rating scores in previously untreated 64 patients and to compare outcomes to controls. The line tracing task asks to follow a given path. It measures the needed interval, the number and duration of contacts to the path. The aiming procedure asks to hit contact plates with a pencil and determines the needed time period and the number of accurate, respectively, missed key strokes. Both tests differed between patients and controls. The line tracing task was more sensitive. The line tracing task asks for a complex motion series performance with more cognitive load. The aiming task prompts for a conduction of preponderant simple, repetitive movement series. Only initially, a complex process of aiming is necessary. Performance of complex motion sequences better differs between patients with Parkinson's disease and controls than conduction of simple, repetitive movement series.
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