Modification of Magnetite Nanoparticles with Triazine-Based Dendrons and Their Application as Drug-Transporting...

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• Acidic bioactive compounds require effective delivery systems.
• Functionalized nanoparticles offer potential for targeted delivery and adsorption.
• Triazine-based dendrons provide unique structural properties for material functionalization.

Purpose of the Study:

• To synthesize magnetite nanoparticles functionalized with triazine-based dendrons.
• To evaluate the adsorptive capabilities of these materials for acidic bioactive compounds.
• To assess the drug-delivery potential of the resulting material-drug complexes.

Main Methods:

• Synthesis of nanosized Fe3O4 particles via co-precipitation.
• Surface amination of magnetite nanoparticles.
• Iterative synthesis of triazine-based dendrons on nanoparticle surfaces using cyanuric chloride and amines.
• Adsorption studies with folic acid, 18β-glycyrrhetinic acid, and vancomycin.
• In vitro drug release studies at pH 2.0 and 7.4.

Main Results:

• High adsorption capacities for folic acid (53.33-401.61 mg g-1), 18β-glycyrrhetinic acid (75.82-223.71 mg g-1), and vancomycin (68.17-132.45 mg g-1).
• Successful formation of material-drug complexes.
• In vitro release studies demonstrated up to 95.2% drug delivery within 48 hours at physiological pH conditions.

Conclusions:

• Magnetite nanoparticles functionalized with triazine-based dendrons are effective sorptive materials for acidic bioactive compounds.
• These materials exhibit significant potential for controlled drug delivery applications in biomedical fields.
• The developed functionalized nanoparticles represent a promising platform for advanced therapeutic strategies.