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Delphinidin and Its Glycosides' War on Cancer: Preclinical Perspectives
Anshul Sharma1, Hyo-Kyoung Choi2, Yeon-Kye Kim3
1Department of Food and Nutrition, College of Bionanotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, Korea.
Abstract:
Until now, several studies have looked at the issue of anthocyanin and cancer, namely the preventive and inhibitory effects of anthocyanins, as well as the underlying molecular processes. However, no targeted review is available regarding the anticarcinogenic effects of delphinidin and its glycosides on various cancers and their plausible molecular mechanisms. Considerable evidence shows significant anticancer properties of delphinidin-rich preparations and delphinidin alone both in vitro and in vivo. This review covers the in vitro and preclinical implications of delphinidin-mediated cell protection and cancer prevention; thus, we strongly recommend that delphinidin-rich preparations be further investigated as potential functional food, dietary antioxidant supplements, and natural health products targeting specific chronic diseases, including cancer. In addition to in vitro investigations, future research should focus on more animal and human studies to determine the true potential of delphinidin.
Insights
Delphinidin, a compound found in anthocyanins, shows significant anticancer properties. Further research into delphinidin-rich foods and supplements could offer natural cancer prevention strategies.
Area of Science:
- Nutritional Biochemistry
- Cancer Research
- Pharmacology
Background:
- Anthocyanins are studied for their cancer preventive and inhibitory effects.
- A gap exists in reviews specifically on delphinidin's anticarcinogenic mechanisms.
- Delphinidin and its glycosides show promise in cancer prevention.
Purpose of the Study:
- To review the anticarcinogenic effects of delphinidin and its glycosides.
- To explore the plausible molecular mechanisms behind delphinidin's anticancer activity.
- To consolidate evidence on delphinidin's role in cancer prevention.
Main Methods:
- Comprehensive literature review of in vitro and preclinical studies.
- Analysis of molecular pathways involved in delphinidin's action.
- Evaluation of evidence for delphinidin-rich preparations.
Main Results:
- Delphinidin exhibits significant anticancer properties in vitro and in vivo.
- Evidence supports delphinidin's role in cell protection and cancer prevention.
- Molecular mechanisms underlying these effects are being elucidated.
Conclusions:
- Delphinidin-rich preparations warrant further investigation as functional foods.
- Potential as dietary antioxidant supplements and natural health products for cancer.
- Future research should include animal and human studies to confirm efficacy.
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