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Updated: Oct 13, 2025

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
ncRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Miguel Hueso1,2, Adrián Mallén2, Marc Suñé-Pou3
1Department of Nephrology, Hospital Universitari de Bellvitge, 08907 L'Hospitalet de Llobregat, Spain.
Abstract:
Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
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