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Dyspepsia: Therapeutic response as a diagnostic tool
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1987
Summary
Non-ulcer dyspepsia (NUD) is challenging to study. A multi cross-over model identified individual cimetidine responders in NUD patients, suggesting a subgroup with reflux symptoms and high acid secretion.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Non-ulcer dyspepsia (NUD) presents diagnostic and therapeutic challenges.
- Conventional clinical trial designs are often suboptimal for heterogeneous conditions like NUD.
Purpose of the Study:
- To introduce and evaluate a multi cross-over model (MCO-model) for studying NUD.
- To identify individual patient responses to cimetidine treatment.
Main Methods:
- A multi cross-over (MCO) model was designed to assess individual drug responses.
- A pilot study and an ongoing study in NUD patients were conducted using the MCO-model.
Main Results:
- The MCO-model showed potential in identifying individual cimetidine responders in dyspepsia patients.
- Preliminary findings suggest a subgroup of NUD patients respond to cimetidine, exhibiting gastroesophageal reflux symptoms and potentially elevated basal acid secretion.
Conclusions:
- The MCO-model is a viable approach for studying heterogeneous conditions like NUD.
- A distinct subgroup of NUD patients responsive to cimetidine may exist, characterized by specific clinical and physiological features.