Related Experiment Video
Updated: Oct 13, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
Long Jieni1, Xue Yazhi1, Zeng Xiaorong1
1Huiqiao Medical Center, Standardized General Practice Training Site, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Insights
Kidney function impacts high-density lipoprotein (HDL) particle size in coronary heart disease patients, with declining kidney function associated with larger HDL particles. Lower HDL particle size remains linked to increased coronary heart disease risk, irrespective of kidney health.
Area of Science:
- Cardiology
- Nephrology
- Lipid Metabolism
Background:
- Renal insufficiency and dyslipidemia are closely linked.
- The impact of kidney function on high-density lipoprotein (HDL) particle size and clinical significance in coronary heart disease (CHD) patients is not well understood.
Purpose of the Study:
- To investigate the relationship between kidney function, HDL particle size (HDL-C/apoA-I), and coronary heart disease.
- To determine if kidney insufficiency affects the association between HDL particle size and coronary artery stenosis severity.
Main Methods:
- Compared HDL particle size (HDL-C/apoA-I) in 419 CHD patients and 105 controls, stratified by estimated glomerular filtration rate (eGFR) and Gensini scores.
- Utilized Student's t test, ANOVA, Pearson's correlation, and logistic regression to analyze associations.
Main Results:
- HDL-C/apoA-I increased as eGFR declined in CHD patients, with significance below 60 mL/min·1.73 m².
- Lower HDL-C/apoA-I correlated with higher CHD occurrence, regardless of kidney insufficiency.
- The association between lower HDL-C/apoA-I and severe coronary stenosis was lost in patients with renal insufficiency.
Conclusions:
- Declining kidney function is associated with larger HDL particles in CHD patients.
- Smaller HDL particles remain a risk factor for CHD occurrence, but their link to stenosis severity is attenuated by renal insufficiency.
Background:
Although renal insufficiency and dyslipidemia are known to be closely associated, the effect of kidney function on the size and clinical value of high-density lipoprotein (HDL) particles remains largely unknown, especially in patients with coronary heart disease.
Methods:
A total of 419 coronary heart disease patients and 105 non-coronary heart disease patients were included. HDL particle size, represented by HDL-C/apoA-I, was compared between groups stratified by estimated glomerular filtration rate (eGFR) and Gensini scores using standard Student's t test and one-way ANOVA. Pearson's correlation test was performed to analyze the association between eGFR and HDL-C/apoA-I in patients with coronary heart disease. The relationship between HDL particle size and the occurrence of coronary heart disease was explored using Univariate logistic regression analysis.
Results:
In patients with coronary heart disease, between-group analysis revealed that HDL-C/apoA-I increased as eGFR declined, and significance appeared as eGFR declined to under 60 ml/min·1.73 m2 (P < 0.001), and Pearson's correlation test also confirmed an inverse correlation between eGFR and HDL-C/apoA-I levels in coronary heart disease patients. When stratified by Gensini scores, in coronary heart disease patients with eGFR ≥ 90 mL/(min·1.73 m2), those with higher Gensini scores had smaller HDL-C/apoA-I. However, with or without kidney insufficiency, smaller HDL-C/apoA-I was associated with a higher occurrence of coronary heart disease (P < 0.05).
Conclusion:
With the presence of renal insufficiency, HDL-C/apoA1 was higher in patients with coronary heart disease. Lower HDL-C/apoA1 was still associated with a higher occurrence of coronary heart disease, but the original association between lower HDL-C/apoA1 and more severe coronary artery stenosis was lost in patients with renal insufficiency.
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:26Coronary Artery Disease IV: Preventive Measures
01:26Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
01:11Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
01:25Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion