Related Experiment Video

Updated: Oct 13, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

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Extrapulmonary CT Findings Predict In-Hospital Mortality in COVID-19. A Systematic Review and Meta-Analysis

Hans-Jonas Meyer1, Andreas Wienke2, Alexey Surov3

  • 1Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.

Academic Radiology
|November 13, 2021
PubMed

Insights

Thoracic computed tomography (CT) identified non-pulmonary findings like pleural effusion, coronary calcification, and mediastinal lymphadenopathy are associated with increased in-hospital mortality in COVID-19 patients. These findings can serve as prognostic biomarkers.

Area of Science:

  • Radiology
  • Pulmonology
  • Infectious Diseases

Background:

  • COVID-19 prognosis is influenced by various factors.
  • Non-pulmonary findings on thoracic CT scans may impact patient outcomes.
  • Identifying reliable prognostic markers is crucial for managing COVID-19 patients.

Purpose of the Study:

  • To investigate the association between extrapulmonary findings on thoracic CT and unfavorable outcomes, including in-hospital mortality, in COVID-19 patients.
  • To evaluate the prognostic value of specific CT-identified extrapulmonary features.

Main Methods:

  • A systematic review and meta-analysis of studies published up to June 2021.
  • Screening of MEDLINE, Cochrane, and SCOPUS databases for relevant studies.
  • Pooled analysis of data from 22 studies including 7859 COVID-19 patients.

Main Results:

  • Pleural effusion (OR 4.60), coronary calcification (OR 2.68), and mediastinal lymphadenopathy (OR 2.02) were significantly associated with increased in-hospital mortality.
  • Pericardial effusion showed a non-significant trend towards increased mortality (OR 1.29).

Conclusions:

  • Pleural effusion, mediastinal lymphadenopathy, and coronary calcification are significant predictors of in-hospital mortality in COVID-19.
  • These CT-identified extrapulmonary findings should be considered as prognostic biomarkers in clinical practice.
Abstract

Keywords:
COVID-19CTMeta analysisSystematic review

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