Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

39.6K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
39.6K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
Introduction to Global Positioning System01:30

Introduction to Global Positioning System

186
The Global Positioning System (GPS) revolutionized positioning on Earth, providing precise location data through satellite ranging. The GPS system was developed in 1978 by the U.S. Department of Defense  for military use, and it became available for civilian applications in 1983, transforming fields including navigation, fleet management, and time synchronization for telecommunications systems.GPS consists of satellites in medium Earth orbit, about 20,200 kilometers above the surface,...
186
Linear time-invariant Systems01:23

Linear time-invariant Systems

520
A system is linear if it displays the characteristics of homogeneity and additivity, together termed the superposition property. This principle is fundamental in all linear systems. Linear time-invariant (LTI) systems include systems with linear elements and constant parameters.
The input-output behavior of an LTI system can be fully defined by its response to an impulsive excitation at its input. Once this impulse response is known, the system's reaction to any other input can be...
520
Basic Continuous Time Signals01:22

Basic Continuous Time Signals

429
Basic continuous-time signals include the unit step function, unit impulse function, and unit ramp function, collectively referred to as singularity functions. Singularity functions are characterized by discontinuities or discontinuous derivatives.
The unit step function, denoted u(t), is zero for negative time values and one for positive time values, exhibiting a discontinuity at t=0. This function often represents abrupt changes, such as the step voltage introduced when turning a car's...
429
Classification of Systems-II01:31

Classification of Systems-II

256
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
256

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.

Nature aging·2026
Same author

Not all gut cellular circadian oscillators are food entrainable.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Circadian Alignment Through Time-Restricted Feeding: Implications for Health and Longevity.

Annual review of nutrition·2026
Same author

Two Stages of Dynamic Metabolic and Transcriptomic Remodeling During the Adaptation to Caloric Restriction in Male C57BL/6J.

bioRxiv : the preprint server for biology·2026
Same author

Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.

Neurobiology of sleep and circadian rhythms·2026
Same author

Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.

iScience·2026
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Oct 13, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Introduction to the Clock System.

Kimberly H Cox1, Joseph S Takahashi2,3

  • 1Department of Neuroscience and Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Advances in Experimental Medicine and Biology
|November 13, 2021
PubMed
Summary
This summary is machine-generated.

This study explores the complex molecular mechanisms underlying circadian rhythms, focusing on cell-autonomous biological clocks and their synchronization. It details core protein interactions within transcriptional feedback loops that regulate daily physiological functions.

Keywords:
Cell-autonomousCircadian rhythmsCore clockFeedback loopsMolecular clock

More Related Videos

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.7K
Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

1.5K

Related Experiment Videos

Last Updated: Oct 13, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.7K
Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
07:59

Author Spotlight: Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

Published on: June 9, 2023

1.5K

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Genetics

Background:

  • Circadian rhythms govern daily physiological processes, including sleep and eating patterns.
  • These rhythms originate from intricate, cell-autonomous clocks synchronized across tissues.
  • Understanding these clocks is crucial for comprehending numerous biological functions.

Purpose of the Study:

  • To elucidate the core molecular machinery of cellular circadian clocks.
  • To summarize the regulation and impact of key protein pairs in feedback loops.
  • To explore human genetics and future research directions in molecular clock studies.

Main Methods:

  • Review of existing literature on circadian clock proteins.
  • Analysis of transcriptional/translational feedback loops.
  • Examination of human genetics data related to circadian rhythms.

Main Results:

  • Identified core protein pairs as key regulators of circadian rhythms.
  • Detailed the complex, tissue-specific responses to external signals.
  • Summarized the impact of these proteins on circadian gene expression.

Conclusions:

  • Cellular circadian clocks are complex and involve intricate protein interactions.
  • Further research into human genetics offers future perspectives on molecular clock mechanisms.
  • Understanding these molecular clocks is vital for various physiological processes.