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DREAM: a database of experimentally supported protein-coding RNAs and drug associations in human cancer
Shupeng Li1, Lulu Li1, Xiangqi Meng1
1Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin, 150086, China.
Abstract:
The Drug Response Gene Expression Associated Map, also referred as "DREAM" ( http://bio-big-data.cn:8080/DREAM ), is a manually curated database of experimentally supported protein-coding RNAs and drugs associations in human cancers. The current version of the DREAM documents 3048 entries about scientific literatures supported drug sensitivity or drug intervention related protein-coding RNAs from PubMed database and 195 high-throughput microarray data about drug sensitivity or drug intervention related protein-coding RNAs data from GEO database. Each entry in DREAM database contains detailed information on protein-coding RNA, drug, cancer, and other information including title, PubMed ID, journal, publish time. The DREAM database also provides some data visualization and online analysis services such as volcano plot, GO/KEGG enrichment function analysis, and novel drug discovery analysis. We hope the DREAM database should serve as a valuable resource for clinical practice and basic research, which could help researchers better understand the effects of protein-coding RNAs on drug response in human cancers.
Insights
The DREAM database compiles experimentally validated associations between protein-coding RNAs and drug responses in human cancers. This resource aids researchers in understanding RNA
Area of Science:
- Genomics and Bioinformatics
- Cancer Therapeutics
- Molecular Biology
Background:
- The Drug Response Gene Expression Associated Map (DREAM) is a manually curated database.
- It documents experimentally supported associations between protein-coding RNAs and drugs in human cancers.
- The current version integrates 3048 literature-supported entries and 195 high-throughput microarray datasets.
Discussion:
- DREAM provides detailed information on protein-coding RNA, drugs, and cancer types.
- It includes data from PubMed and the Gene Expression Omnibus (GEO) databases.
- The database facilitates understanding of drug sensitivity and intervention-related RNAs.
Key Insights:
- Each entry links specific protein-coding RNAs to drug responses in various cancers.
- The database supports research into personalized cancer treatment strategies.
- It highlights the role of specific RNAs in modulating drug efficacy.
Outlook:
- DREAM offers data visualization and online analysis tools, including volcano plots and enrichment analyses.
- It aims to support novel drug discovery and development.
- The database serves as a valuable resource for both clinical practice and fundamental cancer research.
