Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

29.3K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
29.3K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.5K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.5K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.9K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.9K
Stem Cell Culture01:17

Stem Cell Culture

5.6K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.6K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

2.9K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Machine learning multiscale collective cell dynamics: From single-cell characterization to multicellular monolayer modeling.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Circulating Plasma Proteins Influence the Risk of Aortic Dissection via Blood Pressure: A Network Mendelian Randomization and Multi-Omics Study.

Journal of inflammation research·2026
Same author

Machine learning-based prediction of dynamic heterosis for plant height with pathway biomarkers in rice.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2026
Same author

The role of linker on the elevated biosensing performance of a carbohydrate-binding module-tagged sarcosine oxidase.

International journal of biological macromolecules·2026
Same author

Harnessing Phase Separation for the Development of High-Performance Hydrogels.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

UPF3A and UPF3B shape the transcriptome cooperatively yet oppose cell function.

Journal of molecular biology·2026
Same journal

Antibody-secreting cells integrate efficient NMD with non‑canonical UPR signaling to maintain proteostasis and support massive immunoglobulin synthesis.

Journal of molecular biology·2026
Same journal

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.

Journal of molecular biology·2026
Same journal

UPF1 at Work: Structural and Mechanistic Insights Into a Master Regulator of Nonsense-Mediated mRNA Decay.

Journal of molecular biology·2026
Same journal

Structural basis for the pro-amyloidogenic action and ligand binding of a novel W72R variant of human apolipoprotein A-I.

Journal of molecular biology·2026
Same journal

Cryo-EM Structure of the C. elegans Septin Tetramer Reveals a Revised Architecture and Conserved Positional Orthology.

Journal of molecular biology·2026
See all related articles

Related Experiment Video

Updated: Oct 13, 2025

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.4K

Stem Cell-Based Embryo Models: En Route to a Programmable Future.

Yunping Chen1, Yue Shao1

  • 1Institute of Biomechanics and Medical Engineering, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.

Journal of Molecular Biology
|November 14, 2021
PubMed
Summary
This summary is machine-generated.

Synthetic human embryology advances early development understanding. Guided cell organization in stem cell models improves reproducibility and fidelity for crucial embryonic stages like gastrulation and neurulation.

Keywords:
bioengineeringembryo modelshuman embryogenesishuman pluripotent stem cellsmicroenvironment

More Related Videos

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

6.8K
Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

8.4K

Related Experiment Videos

Last Updated: Oct 13, 2025

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

9.4K
Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
12:09

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

6.8K
Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

8.4K

Area of Science:

  • Developmental biology
  • Stem cell biology
  • Bioengineering

Background:

  • Early human embryogenesis (implantation, gastrulation, neurulation) is vital for pregnancy but difficult to study in vivo.
  • In vitro models struggle to replicate the continuous morphogenesis and cytodifferentiation seen in natural development.
  • Current stem cell-based embryo models often lack controllability and reproducibility due to reliance on self-organization.

Purpose of the Study:

  • To provide an overview of advances in synthetic human embryology.
  • To critically review stem cell-based models of human embryonic development.
  • To discuss the potential of guided cell organization for next-generation embryo models.

Main Methods:

  • Review of historical perspectives and recent paradigm-shifting advances in synthetic human embryology.
  • Critical analysis of existing stem cell-based models for implantation, gastrulation, and neurulation.
  • Discussion of bioengineered tools integrated with stem cell biology.

Main Results:

  • Stem cell-based embryo models are crucial for studying early human development.
  • Autonomous self-organization has limitations in controllability, reproducibility, and developmental fidelity.
  • Guided cell organization offers a promising approach to enhance embryo model innovation.

Conclusions:

  • Synthetic human embryology is rapidly advancing, offering new insights into early human development.
  • Integrating self-organization with programmable microenvironmental guidance is key to faithfully reconstructing human embryogenesis in vitro.
  • Future research should focus on leveraging these combined strategies for high-fidelity embryo models.