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Updated: Apr 9, 2026
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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
Published on: May 16, 2025
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Circulating Plasma Proteins Influence the Risk of Aortic Dissection via Blood Pressure: A Network Mendelian
Zhenghao Li1, Jian Liu2, Xiaoxi Fan1
1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Journal of Inflammation Research
|April 8, 2026
Summary
This study identifies key plasma proteins, including CCN3 and COL6A3, causally linked to aortic dissection (AD) risk. Blood pressure (BP) partially mediates these effects, highlighting potential biomarkers and therapeutic targets for AD.
Area of Science:
- Cardiovascular Genetics
- Proteomics
- Systems Biology
Background:
- The relationship between plasma proteins, blood pressure (BP), and aortic dissection (AD) remains unclear.
- Understanding these links is crucial for developing effective AD prevention and treatment strategies.
Purpose of the Study:
- To investigate the causal effects of plasma proteins on AD.
- To determine the mediating role of BP in the protein-AD relationship.
- To identify novel biomarkers and therapeutic targets for AD.
Main Methods:
- Integrated network Mendelian randomization (MR) and multi-omics framework.
- Proteome-wide MR, mediation MR, and colocalization analyses using large-scale GWAS data.
- Sensitivity, replication, and downstream analyses including single-cell RNA sequencing and PheWAS.
Main Results:
- Genetically predicted hypertension and diastolic BP increase AD risk.
- Nine plasma proteins were identified as affecting both BP and AD, notably CCN3, COL6A3, NPPB, and NQO1.
- BP mediated 5.43-22.74% of the effects of these proteins on AD; shared genetic variants were found for CCN3-DBP and COL6A3-AD.
Conclusions:
- CCN3, COL6A3, NPPB, and NQO1 are nominated as potential biomarkers and therapeutic targets for AD.
- Quantifying BP's mediation effect provides insights into AD pathogenesis.
- This research offers novel strategies for early AD identification and intervention.
Keywords:
Mendelian randomizationaortic dissectionblood pressurehypertensionmulti-omicsplasma proteinsMore Related Videos
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