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COVID-19 Survival and its impact on chronic kidney disease

Joshua D Long1, Ian Strohbehn1, Rani Sawtell1

  • 1Massachusetts General Hospital, Department of Medicine, Division of Nephrology, Boston, Massachusetts.

Translational Research : the Journal of Laboratory and Clinical Medicine
|November 14, 2021
PubMed

Insights

Coronavirus disease 2019 (COVID-19) can cause kidney injury, potentially leading to long-term kidney function decline. Genetic factors and healthcare disparities may worsen this impact, particularly in minority groups.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathophysiology

Background:

  • The long-term effects of coronavirus disease 2019 (COVID-19) on kidney function remain largely unknown.
  • A significant percentage of hospitalized COVID-19 patients experience chronic health issues post-infection.

Purpose of the Study:

  • To review the current understanding of COVID-19-associated kidney injury pathophysiology.
  • To summarize the impact of COVID-19 on long-term kidney function and recovery rates from acute kidney injury (AKI).
  • To discuss the role of genetic factors and healthcare disparities in post-COVID-19 kidney function decline.

Main Methods:

  • Comprehensive review of published literature on COVID-19 and kidney injury.
  • Analysis of histopathologic findings from kidney biopsy and autopsy series.
  • Summary of recovery rates from COVID-19-associated AKI.

Main Results:

  • COVID-19 can cause acute kidney injury through tubular, endothelial, and glomerular damage.
  • APOL1 risk alleles and healthcare disparities may disproportionately affect kidney function decline in minority groups post-COVID-19.
  • Data on long-term kidney function decline and chronic kidney disease burden after COVID-19 is still emerging.

Conclusions:

  • COVID-19 poses a significant threat to kidney health, with potential for long-term sequelae.
  • Further prospective studies are crucial to accurately determine the incidence of chronic kidney disease after COVID-19.
  • Addressing genetic predispositions and healthcare disparities is essential for mitigating post-COVID-19 kidney complications.

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