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Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

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Related Experiment Video

Updated: Oct 13, 2025

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The Arrhythmic Phenotype in Cardiomyopathy.

Marco Merlo¹, Giulia Grilli¹, Chiara Cappelletto¹

¹Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Italy.

Heart Failure Clinics

|November 15, 2021

Summary

Sudden cardiac death (SCD) remains a major concern in cardiomyopathies. This review guides clinicians on identifying high-risk patients for SCD prevention, focusing on arrhythmic risk stratification.

Keywords:

Arrhythmic risk stratification Cardiomyopathies Sudden cardiac death

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Published on: July 26, 2018

Area of Science:

Cardiology
Genetics
Internal Medicine

Background:

Cardiomyopathies encompass a range of heart muscle diseases with a wide phenotypic spectrum.
Sudden cardiac death (SCD) is a devastating complication, necessitating effective risk stratification strategies.

Purpose of the Study:

To review current evidence on arrhythmic expression and risk stratification across different cardiomyopathy phenotypes.
To provide practical guidance for clinicians in identifying patients at high risk of SCD.

Main Methods:

Comprehensive literature review of studies on cardiomyopathies, SCD, and risk stratification.
Analysis of arrhythmic manifestations and predictive markers in various cardiomyopathy types.

Main Results:

Implantable cardioverter-defibrillators have shifted focus from 'how' to 'whom' to protect from SCD.
Uncertainty persists regarding the most reliable methods for identifying highest-risk patients.
Evidence synthesis aims to clarify risk stratification approaches for diverse cardiomyopathies.

Conclusions:

Effective risk stratification is crucial for optimizing SCD prevention in cardiomyopathy patients.
A systematic approach to evaluating arrhythmic risk is needed for improved clinical management.
This review offers practical insights to aid clinicians in daily practice.