Differences between radioactive iodine-induced sialadenitis and chronic obstructive parotitis.

Area of Science:

• Salivary Gland Disorders
• Interventional Radiology
• Endocrinology

Background:

• Radioactive iodine-induced sialadenitis (RAIS) and chronic obstructive parotitis (COP) are distinct salivary gland conditions.
• Understanding their differences is crucial for accurate diagnosis and effective treatment.

Purpose of the Study:

• To delineate the diagnostic and therapeutic outcome disparities between RAIS and COP.
• To compare clinical, sialographic, and endoscopic features, alongside treatment results.

Main Methods:

• Comparative analysis of 47 RAIS patients and 50 COP patients treated with interventional endoscopy.
• Evaluation of clinical data, sialography, and endoscopic findings.
• Assessment of treatment outcomes during follow-up.

Main Results:

• RAIS predominantly affects younger females (1:8.4 ratio) with shorter disease duration compared to COP (1:2.1 ratio).
• Sialography in RAIS showed higher rates of main duct obliteration (20.4%), non-visualization (23.7%), and incomplete filling (19.4%).
• Endoscopy revealed increased duct atresia in RAIS (20.4%), with higher rates of duct atresia and gland atrophy (49.5%) observed during follow-up.

Conclusions:

• RAIS presents differently from COP, often in younger females with a shorter history.
• Despite interventional endoscopy, RAIS is associated with a higher incidence of main duct atresia and gland atrophy.