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Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
The Evasion of Antiviral Innate Immunity by Chicken DNA Viruses
Li Gao1, Shijun Zheng1, Yongqiang Wang1
1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Abstract:
The innate immune system constitutes the first line of host defense. Viruses have evolved multiple mechanisms to escape host immune surveillance, which has been explored extensively for human DNA viruses. There is growing evidence showing the interaction between avian DNA viruses and the host innate immune system. In this review, we will survey the present knowledge of chicken DNA viruses, then describe the functions of DNA sensors in avian innate immunity, and finally discuss recent progresses in chicken DNA virus evasion from host innate immune responses.
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