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Pilomatrical carcinosarcoma in the very elderly: A case report
Kazuki Suemune1, Yasushi Adachi1,2,3, Masayuki Takagi4
1Department of Diagnostic Pathology, Toyooka Hospital, Toyooka, Hyogo 668-8501, Japan.
Molecular and Clinical Oncology
|November 15, 2021
Summary
This study details an extremely rare pilomatrical carcinosarcoma case in a 100-year-old male. The findings suggest both tumor components originate from a single source, offering new insights into this rare cancer.
Area of Science:
- Oncology
- Dermatopathology
Background:
- Pilomatrical carcinosarcomas are exceptionally rare neoplasms, with fewer than ten cases documented globally.
- Understanding their pathogenesis is crucial due to their rarity and aggressive nature.
Observation:
- A unique case of pilomatrical carcinosarcoma occurred in the left auricle of a 100-year-old male.
- Histological examination revealed a biphasic tumor composed of pilomatrical carcinoma (atypical basaloid cells and shadow cells) and undifferentiated spindle cell sarcoma.
- Both components exhibited high mitotic activity and a smooth transitional boundary.
Findings:
- Immunohistochemical analysis showed positive β-catenin expression in both carcinoma and sarcoma cells, suggesting a common cellular origin.
- The co-expression of β-catenin supports a monoclonal origin for the distinct histological components.
Implications:
- This case expands the known spectrum of pilomatrical carcinosarcoma.
- The findings provide evidence for a shared developmental pathway, potentially influencing future diagnostic and therapeutic strategies for this rare malignancy.
