Related Experiment Video

Updated: Oct 13, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

361

Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries

Anna Faivre1,2, Thomas Verissimo1,2, Hannah Auwerx1,2

  • 1Laboratory of Nephrology, Geneva University Hospitals, Geneva, Switzerland.

Frontiers in Medicine
|November 15, 2021
PubMed

Insights

Kidney disease alters how kidney cells use glucose. This review explores changes in glucose metabolism during acute kidney injury and chronic kidney disease, offering therapeutic insights.

Area of Science:

  • Nephrology
  • Metabolic pathways
  • Renal cell biology

Background:

  • Acute and chronic kidney disease (CKD) impose significant global healthcare burdens.
  • Kidney injury triggers metabolic adaptations to manage oxygen and nutrient scarcity.
  • Metabolic changes in renal disease can negatively impact fibrosis progression.

Purpose of the Study:

  • To review alterations in proximal tubular cells' glucose metabolism during acute kidney injury (AKI) and CKD.
  • To discuss the consequences of these metabolic shifts.
  • To explore potential therapeutic strategies targeting kidney cell metabolism.

Main Methods:

  • Literature review focusing on glucose metabolism in renal proximal tubular cells.
  • Analysis of metabolic shifts during physiological and pathological kidney conditions.
  • Synthesis of findings related to AKI and CKD.

Main Results:

  • Proximal tubular cells shift from fatty acid oxidation and gluconeogenesis to glycolysis during AKI.
  • Reduced fatty acid oxidation is also observed in CKD.
  • Emerging data indicate significant changes in glucose metabolism in CKD.

Conclusions:

  • Understanding glucose metabolism modifications in kidney disease is crucial.
  • Metabolic reprogramming in proximal tubular cells has implications for disease progression.
  • Targeting metabolic pathways presents potential therapeutic avenues for kidney disease.
Keywords:
acute kidney injurychronic kidney diseasegluconeogenesisglycolysismetabolic shift

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