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Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
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Related Experiment Video

Updated: Oct 13, 2025

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Right Ventricular Mass 12 Years after Osteosarcoma: Multimodality Imaging with Pathologic Correlation.

Badr Bannan1, Huda S Ismail1, Faisal M Alabdulkarim1

  • 1Department of Medical Imaging (B.B., H.S.I., F.M.A., L.J.J., A.T.Y., D.M., D.P.D.), Division of Cardiology (B.S., A.T.Y., G.O.), Keenan Research Centre, Li Ka Shing Knowledge Institute (L.J.J., A.T.Y., D.P.D.), Department of Cardiac Surgery (D.A.L.), and Department of Echocardiography (B.S., G.O.), St. Michael's Hospital, University of Toronto, 30 Bond St, Toronto, ON, Canada, M5B 1W8; Division of Medical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada (T.V., A.G.); Department of Medicine, University of Toronto, Toronto, Canada (A.T.Y., G.O.); Department of Medical Imaging (E.T.N.), Peter Munk Cardiac Centre (E.T.N.), Laboratory Medicine Program, University Health Network (M.A.S.), Department of Laboratory Medicine and Pathobiology (M.A.S.), and Department of Cardiovascular Surgery (R.J.C.), Toronto General Hospital, University of Toronto, Toronto, Canada.

Radiology. Cardiothoracic Imaging
|November 15, 2021
PubMed
Summary
This summary is machine-generated.

A woman with a history of osteosarcoma developed a right ventricular mass. Advanced imaging confirmed metastatic osteosarcoma, successfully treated with debulking, chemotherapy, and targeted therapy.

Keywords:
CTCardiacEchocardiographyHeartImaging SequencesIntraoperativeMR ImagingMetastasesOncologyRight Ventricle

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Area of Science:

  • Cardiology
  • Oncology
  • Radiology

Background:

  • Osteosarcoma is a primary bone cancer that can metastasize.
  • Cardiac metastases are rare but can present as right ventricular masses.

Observation:

  • A 27-year-old woman with a history of femoral osteosarcoma and amputation presented with a large right ventricular mass.
  • Initial thoracic CT was inconclusive, but echocardiography, cardiac CT, and cardiac MRI suggested metastatic osteosarcoma.

Findings:

  • Tumor debulking confirmed osteosarcoma metastasis.
  • Chemotherapy led to a reduction in the cardiac tumor and pulmonary metastases.
  • The patient is undergoing maintenance therapy with a tyrosine kinase inhibitor.

Implications:

  • This case highlights the importance of advanced cardiac imaging in diagnosing rare metastases.
  • Multimodality imaging (echocardiography, CT, MRI) is crucial for characterizing cardiac masses.
  • Successful management involves a combination of surgery, chemotherapy, and targeted therapy for cardiac osteosarcoma metastases.