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Updated: Oct 13, 2025

Synthesis of a Water-soluble Metal–Organic Complex Array
Published on: October 8, 2016
Synthetic Studies toward the Berkeleyacetal Core Architecture
Miguel Adrián Márquez-Cadena1, Wei Zhang1, Rongbiao Tong1
1Department of Chemistry and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong 999077, China.
Abstract:
Berkeleyacetals are structurally complex natural products that have shown potent anti-inflammatory activity. The presence of a highly dense oxygen functionality and a polycyclic ring system presents significant synthetic challenges. Herein, we report an efficient strategy for the construction of the tetracyclic core system of berkeleyacetal. Our synthetic strategy features two cycloadditions ([4+2] and [5+2]) to forge the tetracyclic core and Achmatowicz rearrangement for the preparation of the cyclization substrates containing B and E rings.
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