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Nuclear pore complex maintenance and implications for age-related diseases
Jinqiang Liu1, Martin W Hetzer1
1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Trends in Cell Biology
|November 16, 2021
Summary
Nuclear pore complexes (NPCs) maintain cell function throughout life. NPC integrity is vital for preventing age-related decline and diseases linked to nucleoporin (Nup) malfunction.
Area of Science:
- Cell biology
- Molecular biology
- Aging research
Background:
- Nuclear pore complexes (NPCs) are essential for transport between the nucleus and cytoplasm.
- Long-lived proteins (LLPs) in NPCs suggest a role in lifelong cell function.
- NPC deterioration is linked to aging and degenerative diseases.
Purpose of the Study:
- To review NPC maintenance in proliferating and postmitotic cells.
- To explore the role of nucleoporin (Nup) malfunction in disease pathogenesis.
Main Methods:
- Literature review of NPC maintenance and function.
- Analysis of the link between Nup dysfunction and age-related diseases.
Main Results:
- NPC integrity is crucial for sustained cellular function, especially in postmitotic cells.
- Age-dependent NPC deterioration contributes to cellular aging and disease.
- Nup malfunction is implicated in neurodegenerative and cardiovascular diseases.
Conclusions:
- NPC maintenance is critical for lifelong cell function and preventing age-related diseases.
- Understanding Nup roles can reveal new therapeutic targets for degenerative conditions.
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