Related Experiment Video
Updated: Oct 13, 2025
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
35.4K
Association between Coffee Consumption and Risk of Prostate Cancer in Japanese Men: A Population-Based Cohort Study
Takuya Imatoh1, Norie Sawada2, Taiki Yamaji1
1Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku, Tokyo, Japan.
Summary
Coffee consumption does not appear to affect prostate cancer risk in Japanese men. This large prospective study found no association between coffee intake and the risk of developing total, localized, or advanced prostate cancer.
Area of Science:
- Epidemiology
- Oncology
- Nutritional Science
Background:
- Epidemiological studies on coffee consumption and prostate cancer risk yield controversial results.
- Limited research exists on this association within Asian populations.
- Prostate cancer remains a significant health concern globally.
Purpose of the Study:
- To investigate the association between coffee consumption and prostate cancer risk in a large-scale, prospective, population-based cohort in Japan.
- To address the paucity of research on coffee and prostate cancer in Asian men.
- To provide robust data on a potentially modifiable dietary factor's role in prostate cancer.
Main Methods:
- A cohort of 48,222 Japanese men (aged 40-69) completed coffee consumption questionnaires.
- Participants were followed for incident prostate cancer diagnoses until December 31, 2015.
- Prostate cancer cases were classified as localized or advanced using staging, Gleason score, and differentiation data.
- Cox regression analysis was employed to estimate Hazard Ratios (HR) and 95% Confidence Intervals (95% CI).
Main Results:
- A total of 1,617 incident prostate cancer cases were diagnosed over an average follow-up of 18.8 years.
- No statistically significant association was observed between coffee intake and overall prostate cancer risk.
- Hazard ratios for total, localized, and advanced prostate cancer comparing highest to lowest coffee consumption were 1.08, 1.08, and 1.00, respectively.
- Subgroup analysis, including men with subjective symptoms, yielded similar null findings.
Conclusions:
- Coffee consumption does not appear to impact prostate cancer risk in Japanese men.
- The findings suggest coffee lacks a protective effect against prostate cancer in this population.
- Further research may explore other dietary or lifestyle factors in Asian populations.
More Related Videos
Related Concept Videos
02:59Cancer Prevention
6.4K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.4K
01:21Cancer Survival Analysis
478
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
478
01:29Bias in Epidemiological Studies
778
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
778
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
18
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
18
01:27Confounding in Epidemiological Studies
297
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
297
01:11Observational Studies
10.1K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
10.1K