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Risk Factors of Intractable Epilepsy in Children with Cerebral Palsy

Yehia Hamed Abdel Maksoud1, Hany Abdelaziz Suliman1, Sameh ElSAYED Abdulsamea1

  • 1Pediatric department, Benha University, Benha, Egypt.

Iranian Journal of Child Neurology
|November 16, 2021
PubMed

Insights

Identifying intractable epilepsy in children with cerebral palsy (CP) is crucial. Poor Apgar scores, neonatal seizures, focal epilepsy, and EEG findings predict this condition, enabling early intervention.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Neurodevelopmental Disorders

Background:

  • Cerebral palsy (CP) is a common neurodevelopmental disorder.
  • Epilepsy is a frequent comorbidity in children with CP.
  • Intractable epilepsy poses significant challenges in managing CP patients.

Purpose of the Study:

  • To identify risk factors for intractable epilepsy in children with CP.
  • To develop a predictive model for intractable epilepsy in this population.
  • To inform early therapeutic interventions for refractory seizures.

Main Methods:

  • Retrospective case-control study of 106 children with CP and epilepsy (2015-2020).
  • Data collected included perinatal history, seizure characteristics, imaging, and EEG findings.
  • Statistical analysis to identify predictors of intractable epilepsy.

Main Results:

  • A predictive model for intractable epilepsy was developed.
  • Key predictors include poor Apgar score at 5 minutes and neonatal seizures.
  • Focal epilepsy and focal EEG slowing on background activity were also significant predictors.

Conclusions:

  • A validated model can identify children with CP at high risk for intractable epilepsy.
  • Early identification facilitates timely therapeutic interventions.
  • Reducing the burden of refractory seizures in children with CP is the ultimate goal.
Abstract

Keywords:
Cerebral palsyChildrenIntractable epilepsyRisk factors

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