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ATP binding cassette transporters and cancer: revisiting their controversial role

Parul Sharma1, Navneet Singh2, Siddharth Sharma1

  • 1Department of Biotechnology, Thapar Institute of Engineering & Technology, Patiala, India.

Pharmacogenomics
|November 16, 2021
PubMed

Insights

ATP-binding cassette (ABC) transporters are crucial in drug resistance and chemotherapy. Modulating these transporters offers a promising strategy to overcome multidrug resistance in cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • ATP-binding cassette (ABC) transporters are membrane proteins involved in efflux of compounds.
  • ABC transporters are expressed in various human tissues, including lung, liver, kidney, brain, and intestine.
  • These transporters play a critical role in the development of multidrug resistance (MDR), a major challenge in cancer chemotherapy.

Purpose of the Study:

  • To review the role of ABC transporters in multidrug resistance.
  • To explore strategies for overcoming ABC transporter-mediated drug resistance.
  • To discuss the potential clinical applications of modulating ABC transporters in oncology.

Main Methods:

  • Literature review of preclinical and clinical studies on ABC transporters and multidrug resistance.
  • Analysis of the mechanisms by which ABC transporters contribute to drug efflux and resistance.
  • Evaluation of therapeutic strategies targeting ABC transporters.

Main Results:

  • ABC transporters facilitate the efflux of various compounds, reducing intracellular drug concentrations.
  • Overexpression of ABC transporters is a key mechanism underlying multidrug resistance in cancer.
  • Modulators of ABC transporters are being investigated to enhance chemotherapy efficacy.

Conclusions:

  • Targeting ABC transporters is a viable strategy to overcome multidrug resistance.
  • Further research and clinical trials are needed to translate these findings into effective cancer treatments.
  • Modulation of ABC transporters holds promise for improving patient outcomes in oncology.
Keywords:
ABC transporterscancerinhibitorsmultidrug resistancesubstrates

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