Symptoms Associated with Gadolinium Exposure (SAGE): A Suggested Term

Area of Science:

• Radiology
• Medical Imaging
• Pharmacology

Background:

• Gadolinium-based contrast agents (GBCAs) are widely used in medical imaging.
• Symptoms have been reported following intravascular GBCA administration.
• Existing terminology may imply unverified causal relationships.

Purpose of the Study:

• To introduce a new, neutral term for symptoms after GBCA exposure.
• To facilitate accurate and standardized reporting of these symptoms.
• To support research by avoiding premature causal attribution.

Main Methods:

• Proposal of a new nomenclature by the American College of Radiology Committee on Drugs and Contrast Media.
• Definition and rationale for the proposed term 'Symptoms Associated with Gadolinium Exposure (SAGE)'.

Main Results:

• Introduction of the term SAGE to describe symptoms post-GBCA exposure.
• Advocacy for SAGE over terms implying unproven causality.
• Standardization of symptom reporting is facilitated.

Conclusions:

• The term SAGE offers a scientifically neutral way to describe symptoms.
• SAGE aids researchers and clinicians in precise symptom reporting.
• Standardized reporting through SAGE will enhance the interpretation of related studies.