Bilateral Hand Metastases From a Pleomorphic/Dedifferentiated Leiomyosarcoma: A Case Report.

Area of Science:

• Oncology
• Surgical Pathology

Background:

• Lower extremity leiomyosarcomas are aggressive tumors with high recurrence and metastasis rates.
• Dedifferentiation is a rare process that increases tumor aggressiveness and unpredictability.

Observation:

• A 72-year-old female presented with a rare foot leiomyosarcoma, surgically excised.
• The patient interrupted adjuvant oncological treatment and missed follow-up appointments.
• The tumor dedifferentiated and metastasized to the fingers, an unprecedented site.

Findings:

• This case demonstrates the unpredictable behavior of leiomyosarcoma.
• Patient non-compliance with medical advice significantly impacts treatment outcomes.
• Metastasis to unusual sites like the fingers can occur.

Implications:

• Further research is needed to understand leiomyosarcoma behavior and dedifferentiation.
• Emphasizes the critical role of patient compliance in managing malignant diagnoses.
• Highlights challenges in treating non-compliant patients with advanced cancer.