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Published on: December 6, 2016
Obstructive Sleep Apnea in Underweight Children
Courtney Johnson1, Taylor Leavitt1, Shiva P Daram2
1Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Insights
In underweight children, allergic rhinitis and tonsillar hypertrophy predict obstructive sleep apnea (OSA). Height was also a factor, but no predictors for severe OSA were found in this study.
Area of Science:
- Pediatrics
- Sleep Medicine
- Respiratory Medicine
Background:
- Obstructive sleep apnea (OSA) is a significant health concern in children.
- Underweight status in children presents unique challenges for OSA diagnosis and management.
- Identifying predictors of OSA in this population is crucial for early intervention.
Purpose of the Study:
- To identify predictors of obstructive sleep apnea (OSA) in underweight children.
- To describe the characteristics of underweight children with OSA.
- To inform diagnostic and treatment strategies for OSA in this specific pediatric group.
Main Methods:
- A case-control study was conducted involving underweight children aged 2-18 years who underwent polysomnography.
- Underweight was defined as a body mass index below the 5th percentile.
- Logistic regression analysis was employed to determine predictors of OSA, with an apnea-hypopnea index of 1.0 serving as the threshold.
Main Results:
- Allergic rhinitis (OR, 2.97) and tonsillar hypertrophy (OR, 3.38) were identified as significant predictors of OSA in underweight children.
- Height was negatively correlated with OSA (OR, 0.94), indicating shorter children were more likely to have OSA.
- No demographic or clinical characteristics predicted severe OSA in this cohort.
Conclusions:
- Underweight children with OSA are more likely to present with decreased height, tonsillar hypertrophy, and allergic rhinitis.
- Polysomnography is recommended for symptomatic underweight children with large tonsils and a history of allergies.
- Further research may be needed to understand the nuances of severe OSA in this population.
Objectives:
To determine predictors of obstructive sleep apnea (OSA) in underweight children and to describe the demographic, clinical, and polysomnographic characteristics of an ethnically diverse population of underweight children with OSA.
Study Design:
Case-control study.
Setting:
University of Texas Southwestern Medical Center and Children's Medical Center of Dallas.
Methods:
Underweight children aged 2 to 18 years who underwent a polysomnogram for suspected OSA between January 2014 and December 2020 were included. Underweight was defined as body mass index <5th percentile per Centers for Disease Control and Prevention guidelines. Children with apnea-hypopnea index <1.0 served as a control group. Univariate and multiple logistic regression analysis was used to determine the predictors of OSA. Significance was set at P < .05.
Results:
An overall 124 children met inclusion criteria: mean age, 6.4 years; 50% female; 44% Hispanic, 31% African American, and 18% Caucasian. A total of 83 children had OSA (apnea-hypopnea index ≥1.0). Height was negatively correlated with OSA (odds ratio, 0.94; 95% CI, 0.88-0.99; P = .02) while allergic rhinitis (odds ratio, 2.97; 95% CI, 1.24-7.08; P = .01) and tonsillar hypertrophy (odds ratio, 3.38; 95% CI, 1.42-8.02; P = .01) were predictors for the presence of OSA. No demographic or clinical characteristics were predictors for severe OSA.
Conclusion:
Underweight children with OSA, as compared with those without OSA, are more likely to have decreased height, tonsillar hypertrophy, and allergic rhinitis. There are no predictors of severe OSA in underweight children. We recommend polysomnography for the diagnosis of OSA in symptomatic underweight children with large tonsils, especially when they have a history of allergies.
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